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* P < .05 vs control without siRNA † P < .05, compared with control. All experiments were performed in triplicate. F, Typical examples of the Western blots analyzing A53T α-synuclein turnover during 48 hours under normal conditions (top) or in the presence of LAMP2A siRNA (middle) or 3-MA (bottom). E, Analysis of A53T α-synuclein half-life under control conditions or under conditions inhibiting proteasomal (PSI), chaperone-mediated autophagy (LAMP2A siRNA), macroautophagy (3-MA), or lysosomal (NH 4Cl) function. Both C and D were acquired under identical conditions to compare the staining intensity. D, Immunofluorescence staining of WT α-synuclein SH-SY5Y cells after LAMP2A depletion demonstrating increased α-synuclein content in the cytoplasmic and perinuclear regions. C, Immunofluorescence staining of WT α-synuclein SH-SY5Y cells (green anti–α-synuclein antibody blue, nuclear DAPI) under normal conditions. B, Typical examples of the Western blots analyzing α-synuclein turnover during 48 hours under normal conditions (top) or in the presence of LAMP2A siRNA (middle) or 3-MA and LAMP2A siRNA (bottom). Influence of chaperone-mediated autophagy inhibition (plus siRNA) upon WT α-synuclein half-life and when combined with impaired UPS (PSI), macroautophagy (3-MA), or lysosomal function (ammonium chloride ). A, Wild-type α-synuclein half-life under control conditions and after chaperone-mediated autophagy (lysosomal-associated membrane protein 2A small interfering RNA ), ubiquitin-dependent proteasomal system (UPS) (benzyloxycarbonyl- L-isoleucyl-γ-t-butyl- L-glutamyl- L-alanyl-leucinal ), macroautophagy (3-methyladenine ), or lysosomal (NH 4Cl) inhibition. Degradation pathways of wild-type (WT) α-synuclein. 9/13/2023 0 Comments Ai chatbot onlineWhile the DALL-E tool is free, it does put a limit on the number of prompts a user can do before having to pay. It also lacks regional and country-specific understanding.”Īt the same time, however, it does provide a glimpse into how companies may be able to capitalize on developing more robust virtual assistance, as well as patient and customer care solutions. “It guessed when it was supposed to clarify and sometimes responded to harmful instructions or exhibited biased behavior. “It is very easy for the model to give plausible-sounding but incorrect or nonsensical answers,” he said. Still, Lian Jye Su, a research director at market research firm ABI Research, warns the chatbot is operating “without a contextual understanding of the language.” We’re eager to collect user feedback to aid our ongoing work to improve this system.” “We’re using the Moderation API to warn or block certain types of unsafe content, but we expect it to have some false negatives and positives for now. “While we’ve made efforts to make the model refuse inappropriate requests, it will sometimes respond to harmful instructions or exhibit biased behavior,” Open AI said on its website. Typing a prompt involving a CEO, for example, could prompt a response assuming that the individual is white and male, for example. In fact, Stack Overflow – a Q&A platform for coders and programmers – temporarily banned users from sharing information from ChatGPT, noting that it’s “substantially harmful to the site and to users who are asking or looking for correct answers.”īeyond the issue of spreading incorrect information, the tool could also threaten some written professions, be used to explain problematic concepts, and as with all AI tools, perpetuate biases based on the pool of data on which it’s trained. While ChatGPT successfully fielded a variety of questions submitted by CNN, some responses were noticeably off. In a blog post last week, OpenAI said the “format makes it possible for the tool to answer follow-up questions, admit its mistakes, challenge incorrect premises, and reject inappropriate requests.”Īs of Monday morning, the page to try ChatGPT was down, citing “exceptionally high demand.” “Please hang tight as we work on scaling our systems,” the message said. Other colorful examples including asking for fairy-tale inspired home décor tips and giving it an AP English exam question (it responded with a 5 paragraph essay about Wuthering Heights.) One person asked the chatbot to rewrite the 90s hit song, “Baby Got Back,” in the Style of “The Canterbury Tales ” another wrote a letter to remove a bad account from a credit report (rather than using a credit repair lawyer). “If you plan to be inside, you can wear a t-shirt and jeans or other comfortable clothing.”īut some users are getting very creative. If you plan to be outside, you should wear a light jacket or sweater, long pants, and closed-toe shoes,” ChatGPT responded. “It depends on what activities you plan to do. It’ll even tackle open-ended questions, such as “What’s the meaning of life?” or “What should I wear if it’s 40 degrees out today?” It’s also the next iteration of text-generator GPT-3.Īfter signing up for ChatGPT, users can ask the AI system to field a range of questions, such as “Who was the president of the United States in 1955,” or summarize difficult concepts into something a second grader could understand. It comes from the same company behind DALL-E, which generates a seemingly limitless range of images in response to prompts from users. OpenAI is doing it with ChatGPT,” Levie said on Twitter.īut as with other AI-powered tools, it also poses possible concerns, including for how it could disrupt creative industries, perpetuate biases and spread misinformation.ĬhatGPT is a large language model trained on a massive trove of information online to create its responses. “There’s a certain feeling that happens when a new technology adjusts your thinking about computing. It also captured the attention of some prominent tech leaders, such as Box CEO Aaron Levie. On Monday, Open AI’s co-founder Sam Altman, a prominent Silicon Valley investor, said on Twitter that ChatGPT crossed one million users. Is AI art really art? This California gallery says yes The exhibit features art made with and inspired by OpenAI's AI image generation system DALL-E.Ĭourtesy August Kamp/bitforms gallery sf. August Kamp's 2022 digital image "new experimental version, state of the art" is part of the exhibit "Artificial Imagination" at bitforms gallery in San Francisco. 9/13/2023 0 Comments Voynich manuscript book solvedThe following section of the Voynich MS has traditionally been called the biological section, though others prefer to call it the balneological section. René Zandbergen, a researcher of the manuscript, who runs the popular site Voynich.nu, made a similar argument about the medical nature of the text on his website: Harvard’s Houghton Library curator John Overholt tweeted: Other researchers swiftly shut his claims down, pointing out that his so-called original findings had already been discovered by other experts, and that they didn’t buy the argument about abbreviations. He argued it was a medieval health manual copied from other sources, and its indecipherable cipher consisted of abbreviated medical recipes. The library also summarizes what the book contains, based on the subject matter depicted in the drawings:ġ) botanicals containing drawings of 113 unidentified plant species Ģ) astronomical and astrological drawings including astral charts with radiating circles, suns and moons, Zodiac symbols such as fish (Pisces), a bull (Taurus), and an archer (Sagittarius), nude females emerging from pipes or chimneys, and courtly figures ģ) a biological section containing a myriad of drawings of miniature female nudes, most with swelled abdomens, immersed or wading in fluids and oddly interacting with interconnecting tubes and capsules 4) an elaborate array of nine cosmological medallions, many drawn across several folded folios and depicting possible geographical forms ĥ) pharmaceutical drawings of over 100 different species of medicinal herbs and roots portrayed with jars or vessels in red, blue, or green, andĦ) continuous pages of text, possibly recipes, with star-like flowers marking each entry in the margins.īut what does the language of the book actually mean? Many have attempted to decipher it and in 2017, a history researcher Nicholas Gibbs claimed in the Times Literary Supplement to have uncovered its meaning. Kraus, who purchased it from Voynich’s widow.Īccording to Beinecke Library, the book is described as a “magical or scientific text” and “nearly every page contains botanical, figurative, and scientific drawings of a provincial but lively character, drawn in ink with vibrant washes in various shades of green, brown, yellow, blue, and red.” It passed through various hands, until Voynich purchased the manuscript from the Jesuit College near Rome, and in 1969 it was given to the Yale Library by H. Dee’s son noted that his father owned “a booke…containing nothing butt Hieroglyphicks, which booke his father bestowed much time upon: but I could not heare that hee could make it out.” At one point it emerged in 1903 at a secret book sale by the Society of Jesus in Rome. Rudolph acquired it from English astrologer John Dee, apparently, but believed it was the work of Roger Bacon. Made up of mysterious drawings and indecipherable texts, the manuscript was written in central Europe sometime during the 15th century and once belonged to the library of the Holy Roman Emperor Rudolph II. Rediscovered in 1912 by rare books dealer Wilfrid Voynich, after whom it is named, it now resides in the Beinecke Rare Book and Manuscript Library at Yale University. For more than a century, scholars and experts have puzzled over the mysterious manuscript known today as the “Voynich Manuscript,” which has appeared and vanished through history. 9/12/2023 0 Comments Macos bettersnaptool vs magnetIf you’ve experimented with Windows 7, you may have used something very similar and will be pleased to have one of the greatest window management tools on your shiny new Mac.Ĭompatibility: macOS 10. Just switched to macOS from Windows and already discovered theres no way to. If you need even more than those standard. Never used BetterSnapTool, just from the screenshots and descriptions it looked too technical for me. Theres a 0.99 app for macOS called Magnet that implements aero snap like. This enables you to easily maximize your windows, position them side by side or even resize them to quarters of the screen. Manage your bigger workspace at the speed of light, even on external display. BetterSnapTool allows you to easily manage your window positions and sizes by either dragging them to one of the screens corners or to the top, left or right side of the screen. For all you keystroke lovers, use predefined keyboard shortcuts or create your very own ones that fit your needs.Įxternal Display Support. If you need even more than those standard. Access all features and preferences through menu bar icon sitting right at the top of your screen to be on hand any time you need it. BetterSnapTool allows you to easily manage your window positions and sizes by either dragging them to one of the screen's corners or to the top, left or right side of the screen. Return a window to its previous size by simply dragging it from its snapped position and it will pop back to the shape it had before. Go nice, full, edge-to-edge fullscreen by simply dragging any window to the top of the screen and don’t mess with that tiny green “zoom” button that almost never seems to do what you want it to.Įasy Restore. In just one drag you snap any window into left, right, top and bottom halves and into all four quarters of your screen. 1 I would like to do a little (not a lot) work with a split screen, largely to look at spreadsheets and bank statements simultaneously, and also to compare spreadsheets with data sources. Intel 64 Apple Silicon OS X 10.12 or later. And in Mac App Store, other tools like Magnet, BettersnapTool, and Manico are all similar to Magnet. Maximize them, place them side by side or deploy them into all four quarters of your screen in the blink of an eye. Read 15 user reviews and compare with similar apps on MacUpdate. Magnet is the best windows management app on Mac. Window Magnet will change the way you work with your Mac! Easily snap windows into various sizes and positions by simply dragging them to the edges and corners of the screen. 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Precisely, My Brow Eyebrow Pencil shades 2, 4: STEARIC ACID, RHUS SUCCEDANEA FRUIT WAX, TALC, HYDROGENATED CASTOR OIL, CERA ALBA (BEESWAX), CERA MICROCRISTALLINA (MICROCRYSTALLINE WAX), PARAFFINUM LIQUIDUM (MINERAL OIL), HYDROGENATED COCONUT OIL, HYDROGENATED PALM KERNEL OIL, ALUMINUM HYDROXIDE, HYDROGENATED PALM OIL, TOCOPHEROL, LECITHIN, BHT. Precisely, My Brow Eyebrow Pencil shades 1, 6: STEARIC ACID, TALC, RHUS SUCCEDANEA FRUIT WAX, HYDROGENATED CASTOR OIL, CERA ALBA (BEESWAX), CERA MICROCRISTALLINA (MICROCRYSTALLINE WAX), PARAFFINUM LIQUIDUM (MINERAL OIL), HYDROGENATED COCONUT OIL, HYDROGENATED PALM KERNEL OIL, ALUMINUM HYDROXIDE, HYDROGENATED PALM OIL, TOCOPHEROL, LECITHIN, BHT. Goof Proof Eyebrow Pencil shade 5: STEARIC ACID, HYDROGENATED CASTOR OIL, SYNTHETIC JAPAN WAX, ETHYLHEXYL PALMITATE, CERA ALBA (BEESWAX), SORBITAN SESQUIISOSTEARATE, SYNTHETIC FLUORPHLOGOPITE, TOCOPHEROL, ALUMINUM HYDROXIDE. 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Passion for boardsports starts at a young age and we enjoy seeing girls evolve into young surfers, snowboarders, and skateboarders while wearing ROXY to help them accomplish their goals. Not only do we aim to dress and inspire women, but also kids and children. As a surf, snow, and skateboard brand, we are focused on facilitating riders to do what they love. Are you ready to seize the day in style? ROXY is here to make sure active women everywhere have the clothes, shoes, and accessories they need to look great while living each day to the fullest. ROXY is Always Fashion ForwardĬalling all boardriders. ROXY is fun, fashionable, functional, and free-spirited, become a part of our community today and enjoy our selection of styles. Your energy is contagious, and keeps us motivated to innovate new and exciting products and evolve the brand into the future. 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Here concludes Game 1: A sleepy, 2-1 loss where the offense again failed to be clutch, punctuated by a couple of fun things (Murphy’s homer driving up his trade value, Cade Marlowe’s pair of MLB firsts), but ultimately a disappointing loss that points to so many of the failures of this team: the excellent starting pitching backed by a lackluster offense, the 50-50 mark on the season the platonic ideal of mediocrity from a mediocre team.īut these 2023 Mariners are mediocre, but they won’t make it easy on you. Due to MLB restrictions, Seattle Sports is not permitted to provide a stream of game broadcasts outside of the region. Ground ball merchant Justin Topa replaced him in the eighth, getting Vazquez to ground out and striking out Joey Gallo on three pitches before getting Correa to also ground out. Christian Vázquez got lucky with a little bleeder of a single dribbled down the right field line that gave the Twins a 2-1 lead.Ĭastillo battled through the seventh, running his pitch count up to 104 pitches and ending with nine strikeouts and the two runs on just four hits. He held up until the fifth, when Max Kepler scalded a ground ball base hit leading off, and two batters later Oregon State product Trevor Larnach destroyed a slider that caught too much of the plate for an RBI triple. He was perfect the first time through the lineup, balancing strikeouts with some quick outs, using his changeup effectively at the bottom of the zone and backfooting a ton of sliders that got the lefty-heavy Twins swinging at air. Jordan Balazovic gave up a leadoff single to Julio, but was able to get Suárez and Hernández to ground out before Mike Ford struck out looking on four pitches, leaving Julio standing at third base and Luis Castillo without a well-deserved win.Ĭastillo did everything he could to keep the Mariners in this game and then some. Buy MLB.TV Buy D-backs In-Market Buy Padres In-Market Buy At Bat Watch & Listen Watch MLB.TV Docs & Features Channel Finder MLB. Crawford couldn’t bail the offense out with a clutch hit, hitting a ball opposite-field but right at Trevor Larnach. 177 get reminders NEVER MISS A MOMENT Upcoming Games Monday, July 24 4:40 PM PDT Away Online Seattle Mariners Home CH. After he walked Ty France and Dylan Moore in the seventh, Rocco Baldelli tapped lefty Jovani Moran to come in, which unfortunately ended Cade Marlowe’s day, as Scott Servais opted to pull a righty off his bench, José Caballero. MLB Seattle Mariners Seattle Mariners Monday, July 24 4:40 PM PDT Seattle Mariners Away Online Minnesota Twins Home CH. He has made three appearances this season in which he did not give up an earned run.That traffic did add up, however, as the combination of that and some overall lack of sharpness from Maeda despite the strikeouts led to an inflated pitch count.He averages 5.9 frames per appearance on the mound. Here concludes Game 1: A sleepy, 2-1 loss where the offense again failed to be clutch, punctuated by a couple of fun things (Murphy’s homer driving up his trade value, Cade Marlowe’s pair of. Ryan is looking for his third straight appearance lasting five or more innings.Ryan has 12 quality starts under his belt this season.In his last time out on Saturday, the right-hander went six innings against the Chicago White Sox, giving up four earned runs while surrendering seven hits. It is through a case study of Robinson Cano, a current MLB player, and the Seattle Mariners regarding ticket sales, apparel sales, and TV contracts that I.He is 9-6 with a 3.88 ERA and 141 strikeouts through 118 1/3 innings pitched. Joe Ryan will look to grab his 10th win when he makes the start for the Twins, his 21st of the season.Pitchers for the Twins combine for the No.Minnesota has the third-ranked team ERA across all MLB pitching staffs (3.75).Today’s game was a truly 2023 Mariners game, yet another soul-crushing finale for a team that seems to find no.
9/12/2023 0 Comments 1password iphone extensionAnd if you're unsure of how to create a strong password, a good password manager will always include a strong password generator feature that will create them for you. You can use one to create strong, unique passwords that are exponentially more difficult to hack than something like Fido1986. Using a password manager is a far more effective and convenient mechanism for keeping track of your passwords. It's virtually impossible to remember each individual complex password that you should be creating for each account, which means you need another mechanism to keep track of them all. NordPass estimates that the average internet user has between 70 and 80 passwords. Keep in mind that, by their nature, password managers are extremely attractive targets for cybercriminals, so it's important that you choose one with a track record for security and transparency. This means that once you've entered your passwords into the password manager on one device, they'll automatically show up on all your other devices on which you've installed the app - whether you're using Windows, MacOS, Linux, iOS, Android or a browser extension. The best password managers are cross-platform-compatible and can automatically sync your entire vault across all of your devices. Password manager services usually offer user-friendly web interfaces, apps or browser extensions where you can access your encrypted vault using your master password. You only need to remember a single master password to access the encrypted vault - from which you can access all of the other passwords you have stored. At that point, you may as well tweet out all of your online login credentials to the world.Ī password manager is an online service that provides an encrypted vault where you can store the login credentials for all of your online accounts so you don't have to remember them. Once your password has been compromised, you're vulnerable to credential stuffing attacks, which can result in many of your online accounts being breached. And to help you find one you can trust, we've rounded up the best password managers of 2023 below.Ī weak password is just as easy for criminals to hack as it is for you to remember. Keeping a master list of all your passwords is just asking for trouble, so if you want a safe and convenient way to remember them all, you'll want to invest in a password management service. But remembering dozens of complex and unique codes for every website and service is a serious headache. It's never a good idea to use the same password for every account. 9/12/2023 0 Comments Scratchpad vs doolyWith the close of Dooly’s funding, Ed Sim of boldstart joins Dooly’s board of directors.Īt the time of this announcement, Pouyan Salehi, the CEO of Scratchpad spoke to us on Dooly’s latest funding. Strategic investors that joined the round include Daniel Dines and Brandon Deer (UIPath), Allison Pickens (former COO, Gainsight), Zander Lurie (CEO, SurveyMonkey), Jay Simons (former CEO, Atlassian), Harry Stebbings, and several leaders from product-led growth companies. In rapid succession, the company closed its seed round of $3.3 million, led by boldstart ventures and included BoxGroup and Basement Fund, followed by its Series A of $17 million, led by Addition, with participation from boldstart ventures, Battery Ventures, BoxGroup, Mantis (in partnership with The Chainsmokers), and SV Angel. Our sales people can now focus on selling instead of dealing with Salesforce’s updating nightmare.” How the Funding will Kick-start a New Revolution in Sales Automationĭooly, a sales automation platform, promises to help sales team kick the “SaaS” out of selling operations. We’ve seen massive improvements in productivity – what used to take two hours to do in a day now takes only 30 minutes with Dooly. Kyle Parish, Head of Sales at Figma said, “Dooly changes the game for sales people. Kris added, “Our vision is to create human experiences that users love, helping them stay focused on the high-value, important stuff to become the best version of themselves at work.” This problem exists in every department, but is wildly obvious for revenue teams because every minute spent re-entering data directly equates to lost income.” “Administrative work is the fine print of a job description that no one wants to be doing. Sales Data Analytics and Automation High Octane Fuel for Modern Salesforce UsersĪt the time of this announcement, Kris Hartvigsen, Founder and CEO of Dooly said – This is the problem Dooly sets out to solve, and the company has recently raised $20 million in new capital to scale its platform. Right now, millions of sales professionals are choosing between spending hours re-entering their notes into a CRM or staying in the zone selling. It’s the hard truth– sales professionals spend tons of resources and time to update their CRMs, no matter how advanced these CRMs promise to be. Dooly users report eliminating hours per day re-entering data into Salesforce with Dooly’s integrated notes, while being far more on top of their deals |
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